The dynamiCROP model (www.dynamiCROP.org) is an aspatial, dynamic framework for the quantification and valuation of human health impacts caused by the direct application of plant protection products onto agricultural field crops, such as wheat, and subsequent intake by humans via ingestion. The modelling framework is based on a crop-specific multi-compartment system and analyzes the mass evolution in the different compartments of the system over time. The underlying analytical first order differential equations are solved by means of matrix algebra. Despite the fact that the dynamiCROP model domain is aspatial, the assessment of human health impacts can be performed in a spatial differentiated way according to the underlying input parameters, such as application pattern, crop production area, population etc.